Fluke affect cattle livers, and disease can range from undetectable to life threatening. Signs range from ill thrift to diarrhoea, weight loss and fluid build-up, especially under the jaw (Bottle jaw), the disease can progress to death. Cattle need dosed for fluke, if the disease is advanced then response can be slow due to the amount of liver damage already sustained. All cattle should be wormed at least once per year if they spend the winter in the house, and more often over the winter if they are out wintered. The cost of dosing cattle is greatly outweighed by the financial loss of even low grade fluke infection. There is great variation in the age of fluke which the various fluke doses will kill. Therefore it is important to delay dosing of cattle for the appropriate interval according to which product you plan to use.